Hery Suwito, .- and Jumina, .- and Mustofa, .- and Ni’matuzahroh, .- and Ni Nyoman Tri Puspaningsih, .- (2015) Anticancer and antimicrobial activity of methoxy amino chalcone derivatives. Der Pharma Chemica, 7 (3). pp. 89-94. ISSN 0975-413X

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Abstract

A series of methoxy amino chalcone derivatives have been synthesized and evaluated for their anticancer activity against breast cancer cells line T47D and their antimicrobial activity against Escherichia coli ATCC 25923, Staphylococcus aureus ATCC 25922, and Candida albicans ATCC 10231. The tested compounds exhibited promising anticancer activity, and compound 7 ((E)-1-(4-aminophenyl)-3-phenylprop-2-en-1-one) showed the highest anticancer activity (IC50 5.28 µg/mL). Furthermore, in general the prepared compounds also showed good wide spectrum antimicrobial activity, in which their activity equal to sulfamerazine and sulfadiazine used as positive control

Item Type:	Article
Uncontrolled Keywords:	Methoxy amino chalcone derivatives, anticancer, antimicrobial
Subjects:	Q Science Q Science > Q Science (General) Q Science > QR Microbiology
Divisions:	08. Fakultas Sains dan Teknologi > Program Studi Biologi (S2)
Creators:	Creators NIM Hery Suwito, .- UNSPECIFIED Jumina, .- UNSPECIFIED Mustofa, .- UNSPECIFIED Ni’matuzahroh, .- UNSPECIFIED Ni Nyoman Tri Puspaningsih, .- UNSPECIFIED
Depositing User:	Mr Vega Andi Budiman
Date Deposited:	08 May 2023 00:34
Last Modified:	12 Jun 2023 00:18
URI:	http://repository.unair.ac.id/id/eprint/125863
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