Kurnia H. Rahman, - and Meircurius Dwi Condro Surboyo, - and Desiana Radithia, - and Adiastuti Endah Parmadiati, - and Asdi Wihandono, - and Diah Savitri Ernawati, - (2022) Oral squamous cell carcinoma with essential thrombocythemia and positive JAK2 (V617F) mutation. Journal of Taibah University Medical Sciences, 17 (2). ISSN 1658-3612

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Abstract

Essential thrombocythemia is a condition caused by a high platelet count and a positive JAK2 (V617F) mutation. There is an increasing occurrence of malignancy, such as oral squamous cell carcinoma (OSCC), in patients with essential thrombocythemia. The objective of this case report is to document the novel instance of a patient with OSCC after being diagnosed with essential thrombocythemia and a positive JAK2 (V617F) mutation. The patient was a 42-year-old female who complained of an ulcer and pain in the dextral lateral tongue for three months. After two weeks, the pain diminished; however, there was swelling and tenderness on the ulcer. The patient was diagnosed with essential thrombocythemia and a positive JAK2 (V617F) mutation and began undergoing hydroxyurea therapy three months prior to the OSCC diagnosis. The diagnosis of OSCC was based on exfoliative cytology and MRI. The patient was treated with an antiseptic mouthwash to prevent secondary infection and referred to an oncologist to manage the OSCC. It is possible to use the suspected markers of thrombocytosis and a positive JAK2 (V617F) mutation to define the OSCC diagnosis.

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