Saipul Maulana, - and Tutik Sri Wahyuni, - and Prihartini Widiyanti, - (2023) In silico screening of potential compounds from begonia genus as 3CL protease (3Cl pro) SARS-CoV-2 inhibitors. Journal of Public Health in Africa, 14. pp. 1-6.
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Abstract
Background: The emergence of Coronavirus disease (COVID-19) has been declared a pandemic and made a medical emergency worldwide. Various attempts have been made, including optimizing effective treatments against the disease or developing a vaccine. Since the SARS-CoV-2 protease crystal structure has been discovered, searching for its inhibitors by in silico technique becomes possible. Objective: This study aims to virtually screen the potential of phytoconstituents from the Begonia genus as 3Cl pro-SARS CoV- 2 inhibitors, based on its crucial role in viral replication, hence making these proteases “promising” for the anti-SARS-CoV-2 target.
| Item Type: | Article | ||||||||
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| Uncontrolled Keywords: | Begonia; SARS-CoV-2; 3-Chymotrypsin-Like protease (3Clpro); Molecular docking; Molecular dynamics. | ||||||||
| Subjects: | R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica | ||||||||
| Divisions: | 05. Fakultas Farmasi > Ilmu Kefarmasian | ||||||||
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| Depositing User: | Unnamed user with email indah.fatma@staf.unair.ac.id | ||||||||
| Date Deposited: | 30 May 2023 01:36 | ||||||||
| Last Modified: | 30 May 2023 01:36 | ||||||||
| URI: | http://repository.unair.ac.id/id/eprint/126834 | ||||||||
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