Dita Mernita Setyawatia, DMS and Paulus Budiono Notopuro (2021) A Case Report, Suspected Megakaryoblastic Transformation In A Chronic Myeloid Leukemia Patient. International Journal of Research Publications (IJRP.ORG), 79 (1). pp. 94-99. ISSN 2708-3578

	Text (Jurnal) jurnal A Case Report, Suspected Megakaryoblastic Transformation In.pdf Download (364kB)
	Text (Karil) karil A Case Report, Suspected Megakaryoblastic Transformation In.pdf Download (169kB)
	Text (Turnitin) turnitin A Case Report, Suspected Megakaryoblastic Transformation In A Chronic Myeloid Leukemia Patient.pdf Download (1MB)

Abstract

Backgroud: Chronic Myeloid Leukaemia (CML) is a clonal hematopoiesis stem cell disorder, characterised by reciprocal translocation between chromosomes 9 and chromosomes 22, originally named the ‘Philadelphia chromosome’(Ph). The megakaryoblastic transformation of a CML is extremely rare, consisting <3% of transformed cases. Case Description: A 68-year-old male presented with a CML history since 2000 and received Imatinib therapy. The patient currently showed anemia and splenomegaly. Laboratory results showed hemoglobin 8.1 g/dL, leukocyte count 31,740/:L, platelet count 7,000/:L, Immature Platelet Fraction (IPF) 29.2%, BCR-ABL gene fusion is positive. Bone marrow examination showed CML blastic crisis phase with 45% blasts which had megakaryoblast morphology so it was concluded as a CML that underwent a transformation into megakaryoblastic. The results of bone marrow aspirate using Sysmex-XN1000 showed a very high IPF value which indicated an increased megakaryopoietic proliferative activity. Immunophenotyping examination showed blast population with CD45 dim, low side scatter, with the expression of CD34+, CD33+, CD13+ corresponding to the megakaryoblast area. Examination of the CD41 and CD61 specific megakaryoblast markers was not performed due to reagent limitations.

Actions (login required)

View Item