The MAGE A1-A10 Expression associated with Histopathological Findings of Malignant or Non-Malignant Cells in Peripheral Lung Tumors

Gondo Mastutik, Gondo and Alphania Rahniayu, - and Isnin Anang Marhana, - and Nila Kurniassari, - and Anny Setijo Rahaju, Anny and Mochamad Amin, Mochamad and Heru Fajar Trianto, Heru and Atika, Atika The MAGE A1-A10 Expression associated with Histopathological Findings of Malignant or Non-Malignant Cells in Peripheral Lung Tumors. Asian Pacific Journal of Cancer Prevention, 24 (7). pp. 2329-2335. ISSN p-1513-7368, e-2476-762X

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Official URL: https://journal.waocp.org/article_90704.html

Abstract

Abstract Objective: The objective was to evaluate the expression of melanoma antigen (MAGE) A from A1 to 10 (A1-10) and the individual MAGE A family in the peripheral lung tumors and to analyze its association with histopathological findings. Methods: A cross-sectional study was conducted on 67 samples of peripheral lung tumor obtained by core biopsies from patients with clinical diagnoses such as lung and mediastinal tumors. The specimens were divided into two, one to perform histopathological diagnosis and the last for mRNA MAGE A examination. A Nested polymerase chain reaction (PCR) was performed using universal primer, MF10/MR10 and MF10/MR12. The collected data were analyzed by appropriate statistical techniques. Result: The histopathological finding showed 41 (61.2 %) of specimens as malignant cells and 26 (38.8 %) of specimens as non-malignant cells. MAGE A1-10 was expressed at 47 (70.1 %) and MAGE A1-6 was expressed at 25 (37.3 %) of specimens. In a malignant cell, MAGE A1-10 and MAGE A1-6 were expressed at 33 (80.5 %) and 19 (46.3 %), respectively. In non-malignant cells, MAGE A1-10 and MAGE A1-6 were expressed at 14 (53.9 %) and 6 (23.1 %,) respectively. The MAGE A1-10 and MAGE A8 expressions were significantly associated with histopathological findings of malignant or non-malignant cells. The sensitivity, specificity, and diagnostic accuracy of MAGE A1-10 were 80.5 %, 46.2 %, and 67.2 %, respectively; while for MAGE A8 were 41.5 %, 88.5 %, and 59.7 %, respectively. Conclusion: The MAGE A1-10 expression was the most commonly detected and associated with the histopathological finding. Moreover, it was more sensitive and specific and had higher diagnostic accuracy than others. Therefore, the MAGE A1-10 assay may improve the accuracy of the diagnosis of malignancy in peripheral lung tumors.

Item Type: Article
Subjects: R Medicine > R Medicine (General) > R5-920 Medicine (General)
Divisions: 01. Fakultas Kedokteran > Patologi Anatomi
Creators:
CreatorsNIM
Gondo Mastutik, GondoNIDN0027067304
Alphania Rahniayu, -UNSPECIFIED
Isnin Anang Marhana, -UNSPECIFIED
Nila Kurniassari, -UNSPECIFIED
Anny Setijo Rahaju, AnnyNIDN0020097009
Mochamad Amin, MochamadNIDN8804680018
Heru Fajar Trianto, HeruUNSPECIFIED
Atika, AtikaNIDN0009027002
Depositing User: arys fk
Date Deposited: 05 Aug 2023 11:50
Last Modified: 29 May 2024 00:09
URI: http://repository.unair.ac.id/id/eprint/127910
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