Nur Aisiyah Widjaja, Nur and Rizka Arifani, - and Roedi Irawan, - (2023) Cut-off value of Waist-to-Hip Ratio as a pedictor of metabolic syndrome in adolescents with obesity. Acta Biomedica, 94 (3). ISSN 1750-4589

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Abstract

Abstract.Background and aim: Metabolic syndrome is present in 7% of adolescents and 19 to 35% in obese adolescents, and the cause of this condition has not been fully understood. Early identification of the risk involved could be an initial step in preventing a metabolic syndrome. Increased waist circumference, which is a parameter of central obesity, is also risk factor for this condition. This study aims to determine the pos-sibility cut-off value of waist-to-hip (WHR) as a predictor of metabolic syndrome. Methods: We studied 208 obese adolescents between the ages of 13 to 18 years from junior and senior high schools who living in rural dan urban areas in East Java. These obese adolescents were divided into two groups, namely with and without a metabolic syndrome. Anthropometric measurements, including waist-to-hip ratio (WHR), were carried out to analyze the cut-off values between the two groups. Results: 208 obese adolescents (51.4% males and 48.6% females) without the metabolic syndrome and 104 obese adolescents with metabolic syndrome were evaluated. There was a significant relationship between WHR and metabolic syndrome in obese adolescents (r = 0.203, P = 0.003). Those adolescents with a high WHR value > 0.891 had twice risk to develop meta-bolic syndrome compared to those with lower (OR 2.033; 95% CI = 1.165-3.545). Conclusions: Increased waist-to-hip ratio > 0.89 in adolescents was associated with higher risk to develop metabolic syndrome and can be proposed as a predictor for metabolic syndrome in obese adolescents. (www.actabiomedica.it)Key words: Waist-to-hip ratio, Metabolic Syndrome, Adolescence, Risk FactorsIntroductionMetabolic syndrome (MetS), also known as “Insulin Resistance Syndrome” or “Syndrome X”, has an increas-ing prevalence in children and adolescents. The cause of this condition has not been fully understood (1). There-fore, early identification of MetS risk factors and adopt-ing suitable preventive measures is an essential step in preventing its occurrence (2,3). One of the components of MetS is central obesity, which can be measured using various anthropometric parameters, such as waist and hip circumferences, and waist-hip ratio (WHR). Further-more, the periodic measurement of these parameters can be used for early identification of MetS (4). The cut-off value of WHR can be used as a predicting indicator of metabolic syndrome in obese children (5). However, this value varies among different countries (6). This study aims to determine the cut-off value of WHR as a predictor of metabolic syndrome in obese adolescents in Indonesia.Materials and methodsStudy population and designThis is an observational case-control study per-formed between January to May 2020 on obese ado-lescents with and without the metabolic syndrome. The cut-off value that discriminates those with versus those wthout the metabolic syndrome was searched.

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