Andy Suryadi A. M. and Rr. Retno Widyowati, NIDN. 0005017701 and Tri Widiandani, NIDN. 0004128001 and Siswandono, NIDN. 0002105207 (2018) Structure Modifications of Pinostrobin from Boesenbergia pandurata Roxb. Schlecht Extract. In: Bromo Conference, Symposium on Natural Products & Biodiversity, 11-12 July 2018, Surabaya, Indonesia. (Unpublished)

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Abstract

Background: Boesenbergia pandurate Roxb. Schlecht. (Zingiberaceae) is one of the ginger plants that has been identified to contain pinostrobin. It determined as an anti-inflammatory and analgesic activities through inhibition of COX2 enzymes. Objective: The objective of this research was to obtain a pinostrobin derivative of acylation reactions between pinostrobin and acyl chloride derivatives. Methods: The structure modifications of pinostrobin were obtained by Schotten-Baumann method through nucleophilic substitution reactions between pinostrobin and acyl chloride derivatives. Results: The investigation of structure modifications of pinostrobin from this plant has demonstrated the present of pinostrobin acetate (1) and pinostrobin butyrate (2) based on the spectrometric analysis such NMR. Conclusion: Pinostrobin acetate and pinostrobin butyrate which are derivatives of pinostrobin can be synthesized using the Schotten-Baumann method.

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