THERESA BINAYU PRABHAWATI, 051511133222 (2019) PENGARUH SISTEM DISPERSI PADAT ANDROGRAFOLIDA-KITOSAN TERHADAP BIOAVAILABILITAS ANDROGRAFOLIDA. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Andrographolide (ADG) is a diterpene lactone substance from Andrographis paniculata plants has pharmacological activities like antiinflammatory, hepatoprotective, anticancer, and anti-malarial. Andrographolide is class 2 candidate of the Biopharmaceutical Classification System (BCS), it has a high cellular permeability and low solubility. Andrographolide-chitosan solid dispersion system (SDS ADG-CTS) can be used to improve solubility and dissolution of andrographolide so the bioavailability andrographolide can also increase. The aim of this study was to determine the bioavailability (AUC0−~) SDS ADG-CTS prepared using the method of solubilisation and spray drying. Bioavailability test is performed using New Zealand male rabbits divided into three treatments group: ADG , ADG-CTS physical mixture, and SDS ADG-CTS with given orally. Blood samples was taken at specific interval times during 3 hours. Andrographolide concentration in plasma was determined using HPLC. The results of bioavailability test (parameter AUC0-180) andrographolide-chitosan solid dispersion system increased 3.1 times compared to ADG and statistically significantly increased compared to ADG and ADG-CTS physical mixture. It can be concluded that SDS ADG-CTS was able to increase the bioavailability of ADG.

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