Sin War Naw (2020) The Antioxidant, Antidiabetic, Anticancer Activities And Toxicity Of Extract Of Sargassum Duplicatum And Padina Tetrastromatica. Thesis thesis, UNIVERSITAS AIRLANGGA.

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	Text 3. ABSTRACT.pdf Download (115kB)
	Text 4. CHAPTER I INTRODUCTION.pdf Download (137kB)
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Abstract

In this current study, the two seaweed species of Sargassum duplicatum and Padina tetrastromatica were collected from oil extraction site and non-oil extraction site at Madura Island. The collected seaweeds were investigated for their phytochemical constituents, total phenolic contents (TPC), antioxidant activities, antidiabetic activities, anticancer activities, toxicities by using Folin-Ciocalteus method, the 2,2-diphernyl-1 picrylhydrazyl (DPPH), α-glucosidase enzyme, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and Brine Shrimp Lethality Test (BSLT) , respectively. The crude extracts (C), normal hexane (N), ethyl acetate (E), methanol residue fractions (M) were studied. The higher TCP (589.79±7.14g and 102.36±5.77e mg GAE/g) were observed in ethyl acetate fraction of S. duplicatum and P. tetrastromatica from non-oil extraction site. Meanwhile, crude extracts and all fractions showed potent antioxidant, antidiabetic and cytotoxic activities with ethyl acetate fraction of P. tetrastromatica from non-oil extraction site displaying with the best activity (IC50 25.25±5.15a,b, 249.12±1.77b and 70.56±2.56a μg/mL, respectively). In brine shrimp assay, all fractions of S. duplicatum and P. tetrastromatica from two different sits were non-toxic after 24 h of incubation times. However, normal hexane fraction of S. duplicatum and P. tetrastromatica from oil extraction site were considered to be mild toxic while those from non-oil extraction had nontoxic after 48 h of incubation. Based on the findings of the current study, it is factual to conclude that the marine seaweed extracts from Mudra Island have antioxidant, antidiabetic, and cytotoxic activity, which could be recommended for future submission in medicinal way and exploring novel drugs from the marine products

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