Ernik Zuli Yanti, - and Herry Agoes Hermadi, - and Purwo Sri Rejeki, - and Yeni Dhamayanti, - and Widjiati, - and Epy Muhammad Luqman, - (2020) The Increasing Inflammatory Cells, Degeneration and Duodenal Necrosis on Infant Mice from Carbofuran Exposed Mothers. Journal of International Dental and Medical Research, 13 (2). pp. 785-790. ISSN 1309-100X

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Abstract

This study was designed to observe the effect of carbofuran induction as a trigger for ROS on duodenal histopathology in infant mice exposed to transmammary. This study aimed to evaluate any inflammation, degeneration and duodenal necrosis in the infant mice from the carbofuran exposed mothers during the lactation periods. There were 20 strain Balb/C mice were divided into four groups, each group contained five mice. Control Group induced with 0.1 ml/kg Body Weight (BW) of aquades, Carbofuran Group 1/16 LD50 with the dose of 0.3125 mg/kg BW, carbofuran Group 1/8 LD50 with the dose of 0.625 mg/kg BW, and Carbofuran Group 1/4 LD50 with the dose of 1.25 mg/kg BW. Mice mothers were exposed to carbofuran orally from Day 1 to 9 after giving birth. On Day 10, infant mice were sacrificed, one from each parent. Next, the infant mice duodenums were stained using hematoxilin-eosin. The results show that carbofuran exposure causes an increase in inflammation (p = 0.001), degeneration (p = 0.001) and necrosis (p = 0.002). Carbofuran leads to oxidative duodenal stress in infant mice which triggers the increase in inflammation, degeneration and necrosis in infant mice’s duodenum along with the increasing doses.

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