Ratih Dewi Saputri, .- and Rurini Retnowati, .- and Unang Supratman, .- and Tjitjik Srie Tjahjandarie, .- and Mulyadi Tanjung*, .- (2023) Three novel quinolinone alkaloids from the leaves of Melicope denhamii. Natural Product Research.

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Abstract

Three previously unreported quinolinone alkaloids: melicodenines J-L (1-3) and six known compounds (4-9), were isolated from the leaves of Melicope denhamii (Seem) T.G. Hartley. The structures of three quinolinone alkaloids were identified based on HRESIMS and NMR spectra. Compounds 1-9 were assayed in three cancer cells (MCF-7, HeLa, and P-388). Compounds 1 and 5 showed high cytotoxic activity against HeLa cells with IC50 values of 1.8 and 0.8 µM, respectively.

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