Sucutiniranes A and B, new cassane-type diterpenes from Bowdichia nitida

Yosuke Matsuno, - and Jun Deguchi, - and Yusuke Hirasawa, - and Kunio Ohyama, - and Hiroo Toyoda, - and Chieko Hirobe, - and Wiwied Ekasari, - and Aty Widyawaruyanti, - and Noor Cholies Zaini, - and Hiroshi Morita, - (2008) Sucutiniranes A and B, new cassane-type diterpenes from Bowdichia nitida. Bioorganic and Medicinal Chemistry Letters, 18 (13). pp. 3774-3777. ISSN 0960-894X

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Official URL: https://www.sciencedirect.com/science/article/abs/...

Abstract

Two new cassane-type diterpenes, sucutiniranes A (1) and B (2), have been isolated from the seeds of Bowdichia nitida together with 6α-acetoxyvouacapane (3) and 6α,7β-diacetoxyvouacapane (4), and the structures of 1 and 2 were elucidated by using 2D NMR data and chemical correlations. Sucutinirane A (1) and 3 showed a moderate cytotoxicity against human colon carcinoma COLO201 cells, and 6α,7β-diacetoxyvouacapane (4) showed in vitro antiplasmodial activity against parasite Plasmodium falciparum 3D7.

Item Type: Article
Uncontrolled Keywords: Diterpene, Sucutinirane A, Sucutinirane B, Bowdichia nitida, Cytotoxicity, Antiplasmodial activity
Subjects: R Medicine
R Medicine > RS Pharmacy and materia medica
R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
R Medicine > RS Pharmacy and materia medica > RS200-201 Pharmaceutical dosage forms
Divisions: 05. Fakultas Farmasi > Farmakognosi Fitokimia
Creators:
CreatorsNIM
Yosuke Matsuno, --
Jun Deguchi, --
Yusuke Hirasawa, --
Kunio Ohyama, --
Hiroo Toyoda, --
Chieko Hirobe, --
Wiwied Ekasari, -NIDN0022016902
Aty Widyawaruyanti, -NIDN0026046210
Noor Cholies Zaini, --
Hiroshi Morita, --
Depositing User: Mr M. Fuad Sofyan
Date Deposited: 30 May 2022 00:29
Last Modified: 02 Aug 2022 08:16
URI: http://repository.unair.ac.id/id/eprint/116537
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