Lidya Tumewu, - and Evhy Apryani, - and Mei Ria Santi, - and Tutik Sri Wahyuni, - and Adita Ayu Permanasari, - and Myrna Adianti, - and Chie Aoki, - and Aty Widyawaruyanti, - and Achmad Fuad Hafid, - and Maria Inge Lusida, - and Hak Hotta, - (2014) Anti Hepatitis C virus activity screening on Harpullia arborea extracts and isolated compound. In: Proceeding the 1st International Conference on Pharmaceutics and Pharmaceutical Sciences. Fakultas Farmasi Universitas Airlangga, pp. 165-167. ISBN 978.602-72333.0-0

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Abstract

Hepatitis C is a major healthcare problem worldwide. Available therapy for hepatitis C treatment is very expensive and probably not be accessible for all patients. Regarding to this reason, the development of safe and inexpensive antiviral drugs is required. Natural products as a source of new drugs are potential to study. Some antiHCV substances from plants were obtained (Wahyuni, 2013; Adianti, 2014; Aoki, 2014). Harpullia arborea (tulip wood tree) is a member of Sapindaceae family commonly known as kayu pacat in Indonesia (Basuni, 1997). Traditionally, watery exudates from barks and fruits is used as leech repellant, oil extracted from seeds is a source of antirheumatics (Singh, 2011). H.arborea seeds extract also shown antibacterial activities against various strains of bacteria. H.arborea seeds contain glycosides, steroids, saponins and resins (Gowri, 2009). A norhopane triterpenoid also isolated from the leaves of H.arborea (Poovapatthanachart, 2008). This study was conducted to determine antiHCV activity of H.arborea extracts and isolated compound.

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