Desi Wulansari D, - and Widjiati, - and Wurlina, - and Sri Pantja Madyawati, - and Viski Fitri Hendrawan, - and Epy Muhammad Luqman, - (2021) The Effect of Epigallocatechin Gallate (EGCG) to Ovary Activity and The Expression of LH Receptors in Female Rat (Rattus norvegicus). International Journal of Pharmaceutical Research, 13 (1). pp. 4826-4830. ISSN 0975-2366

	Text (Artikel) Artikel_29_Epy_Muhammad_Luqman.pdf Download (1MB)
	Text (Kesesuaian Bidang Ilmu) Kesesuaian_29_Epy_M_Luqman.pdf Download (2MB)
	Text (Turn It In) Similarity_29_Epy_Muhammad_Luqman.pdf Download (1MB)
	Text (Bukti Korespondensi) Korespondensi_29_Epy_Muhammad_Luqman.pdf Download (1MB)

Abstract

Green tea polyphenol, epigallocatechin gallate (EGCG) has been proposing as a cancer chemopreventive, antioxidant and has inhibitor effect in steroidogenesis. The aim of the research was to determine the effect of EGCG on the estrous cycle and expression of LH receptors in female rat (Rattus norvegicus). This research was using 24 female rats, 2-3 months age divided into four groups rat (Rattus norvegicus) were treated with 4.05, 8.1, 12.15 mg EGCG/100 g orally in seven days to study their acute effect on ovarian activity and the expression of luteinizing hormone (LH) receptors. Vagina smear histology has been used as an index of ovarian activity. Daily vagina smears were taken for six days. The expression of LH receptors were examined by immunohistochemistry avidin-biotin complex method. The result showed that EGCG significantly reduced the expression of LH receptors (p < 0.05) and extended follicular phase (0.2-19.4%). The decrease in LH receptors were consistent with an increase in the dose of EGCG. The smallest dose of EGCG (4.05 mg) had given the lowest effect in reduced the expression of LH receptors and extended follicular phase

Actions (login required)

View Item