Johanes Nugroho Eko Putranto, Johanes and Risa Titis Wijayanti, Risa Effect of Home-Based Exercise Training on Plasma Vascular Endothelial Growth Factor and Ankle- Brachial Index in Patients With Mild Peripheral Artery Disease: A Pilot Study. Vascular Disease Management®, 16 (12). ISSN 1553-8036

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Abstract

Abstract Background: Peripheral artery disease (PAD) is a manifestation of atherosclerosis in the peripheral arteries of the inferior extremities, and is associated with high morbidity and mortality rates. Increased levels of vascular endothelial growth factor (VEGF) can stimulate the process of angiogenesis and collateral artery formation in patients with PAD. Production of VEGF can be improved with regular exercise training. Home-based training offers more convenience in terms of time and place than does standard exercise training. Objective: The study aims to clarify the effect of home-based exercise training on VEGF level and ankle-brachial index (ABI) in patients with PAD. Methods: In a quasi-experimental study, 19 patients with PAD underwent home-based exercise training for 8 weeks. VEGF levels were measured and ABI was evaluated before and after 8 weeks of home-based exercise training. Before exercise training, 10 patients had an ABI of 0.9 or less in the right limb, and 13 had an ABI of 0.9 or lower in the left limb. Results: The results showed that both ABIs significantly increased after home-based exercise training (right ABI: mean difference = 0.11; 95% confidence interval [CI], 0.06–0.16; P=0.001; left ABI: mean difference = 0.12; 95% CI, 0.09–0.16; P=0.000). The levels of VEGF before and after home-based exercise training VEGF level were significantly different (P=0.0001) Conclusion: Home-based exercise training improved VEGF level and ABI in patients with PAD.

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