Johanes Nugroho Eko Putranto, Johanes and Ruth Gunadi, Ruth Acute Limb Ischemia in the Young: A Rare Case of Essential Thrombocytosis. Case Reports in Cardiology. ISSN 2090-6412

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Abstract

Abstract Acute limb ischemia (ALI) is rarely observed in young populations. The hypercoagulable state is a notable cause of ALI other than artery disease progression and cardiac embolization. A hypercoagulable state occurs in essential thrombocytosis because of the overproduction of hematopoietic cells secondary to the mutation of the JAK2, CALR, or MPL genes. We report a rare case of a 37-year-old woman presenting with Rutherford IIA ALI in the left lower extremity. Laboratory data revealed she had a platelet count reaching up to 1.38 mil/μL, with other blood profiles being normal. A JAK2 mutation examination was later performed and proved positive. After careful management with catheter-directed thrombolysis, surgical thrombectomy, and cytoreductive therapy using hydroxyurea, the symptoms subsided and eventually restored the patient to physical activity in less than one month.

Item Type:	Article
Subjects:	R Medicine > R Medicine (General) > R5-920 Medicine (General)
Divisions:	01. Fakultas Kedokteran > Ilmu Kardiologi Dan Kedokteran Vaskular (Spesialis)
Creators:	Creators NIM Johanes Nugroho Eko Putranto, Johanes NIDK: 8866900016 Ruth Gunadi, Ruth UNSPECIFIED
Depositing User:	arys fk
Date Deposited:	25 Feb 2023 10:51
Last Modified:	25 Feb 2023 10:51
URI:	http://repository.unair.ac.id/id/eprint/120140
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